Innovigen Human HSCs Media

Innovigen Human HSCs Media is a specialized cell culture medium meticulously designed to grow, maintain, and expand human hematopoietic stem cells (HSCs) and progenitor cells. This medium is optimized for applications in basic research, regenerative medicine, and clinical studies requiring precise control over HSC proliferation and differentiation. It is particularly suited for blood cell development studies, stem cell population expansion, and cell therapy applications.

Key features:

• Serum-Free or Low-Serum Options: Available in formulations tailored to specific experimental needs.
• Optimized for Human HSPCs: Promotes the growth and maintenance of hematopoietic stem/progenitor cells (HSPCs), ensuring high viability and functionality.
• Supports Proliferation and Differentiation: Facilitates controlled expansion while maintaining the ability to differentiate into multiple blood cell lineages.
• Ex Vivo Expansion of CD34⁺ Cells: Ideal for expanding CD34⁺ cells, a critical marker for primitive hematopoietic cells used in transplantation and research.

Applications:

• Expansion and maintenance of human hematopoietic stem cells (HSCs).
• Culture of human hematopoietic progenitor cells (HSPCs).
• Research in stem cell biology, blood cell development, and cell therapy.
• Ex vivo manipulation of CD34⁺ cells for transplantation or gene editing studies.

References:

1. Fares, I., et al.. "UM171 expands human hematopoietic stem cells and promotes      engraftment after transplantation." Science 345.6203 (2014): 1509–1512. This study highlights the importance of optimized media in expanding functional HSCs for clinical applications.
2. Sugai, S., et al.. "Hepatocellular carcinoma cell sensitivity to Vγ9Vδ2 T      lymphocyte-mediated killing is increased by zoledronate." International      Journal of Oncology 48.5 (2016): 1794–1804. Demonstrates the role of specialized media in enhancing HSC-based immunotherapy approaches.
3. Cohen, S., et al.. "Ex vivo expansion of cord blood CD34+ cells improves      engraftment in patients with hematologic malignancies." Blood Advances 4.19 (2020): 4567–4577. Discusses how optimized culture systems improve HSC functionality for transplantation.
4. Hua, P., et al.. "CPI203 enhances ex vivo expansion of human CD34+ cells by      epigenetic modulation." Stem Cell Reports 15.6 (2020): 1305–1317. Explore the use of small molecules in culture media to boost HSC expansion.
5. Boitano, A., et al.. "Aryl hydrocarbon receptor antagonists promote the      expansion of human hematopoietic stem cells." Science 329.5997 (2010): 1345–1348. Highlights advancements in serum-free media formulations for HSC culture.